From the north (St. Charles, Alton, IL, etc.):

Take I-270 south to Manchester Road. Go west (the exit splits east & west), stay in the right lane, and almost immediately take the exit to Des Peres Road. At the bottom of the exit ramp, take the left lane and turn left onto Des Peres Road (going North). The church is half a mile up Des Peres Road on the left.

From the south and southern Illinois:

Take I-270 north to Manchester Road. As you exit, stay in the next-to left lane going west. The west exit lanes cross the eastbound lanes of Manchester Road and take you over to the westbound lanes of Manchester Road. As you merge onto Manchester Road, head to the right lane and take the Des Peres Road exit on the far right. At the bottom of the exit ramp, take the left lane and turn left onto Des Peres Road (going North). The church is half a mile up Des Peres Road on the left.